Cancer research continues to investigate the process by which a tumor generates metastases (replicates) in one organ or another. When the reasons for this process are thoroughly known, this would allow us to predict where one of the most critical phases of cancer will occur and it would be easier to avoid it.
As you can see in the video that heads this post, the most accepted hypothesis is that for a metastasis, seeds that disperse tumor cells and a fertile substrate that host them are needed, that is, a cozy environment in the target organ. This hypothesis has been raised. Stephen Paget.
Now, a multidisciplinary and international team of scientists composed of researchers from CNIO, Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center, has not only confirmed this theory and revealed the molecular mechanisms that make it possible, but it has also expanded. First, the work corroborates the existence of exosomes, a key piece in the process of metastasis, as explained by the co-author of the study and head of the CNIO Microenvironment and Metastasis Group, Hector Hairstyle:
The researchers collected evidence that the tumors release millions of vesicles loaded with proteins and genetic material, called exosomes, that act as a tumor advance and whose mission is to get the target organs to be prepared to accommodate the tumor cells.